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Marfan Syndrome
cases in Malaysia:
src: Rare Disease Malaysia 2024
General
Marfan
PWS
OI
Air escapes from the lung into the chest, and causes chest pain, breathing difficulty, low oxygen in body.
Spine bends more over time which causes poor posture, back pain, and difficulty breathing if severe.
Aortic dissection can cause severe internal bleeding. Enlarged aorta which makes heart works harder.
Bones in the joints move out of place which causes pain, swelling, limited movement, and long-term joint damage.
Retinal detachment which can causes vision loss.
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Prader-Willi Syndrome
cases in Malaysia:
src: Bernama, 2025
General
Marfan
PWS
OI
Hormonal imbalance affects reproductive development, making natural fertility difficult.
Rapid weight gain and low muscle mass increase the risk of developing type 2 diabetes.
Obesity and low muscle tone strain the heart, raising the chance of heart-related complications.
Excess body weight and abnormal hormone regulation contribute to high blood pressure.
Weak muscles and excess fat around the chest make breathing and sleep-related breathing disorders common.
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OI Cases in Malaysia:
src: Rare Disease Malaysia 2024
General
Marfan
PWS
OI
Weak tooth structure leads to easy chipping, discoloration, and early wear.
Curved spine (scoliosis/kyphosis) can worsen mobility and affect breathing and organ function.
Abnormal or fragile ear bones interfere with sound transmission.
Loose joints and weak connective tissue increase the risk of dislocations and chronic pain.
Chest wall deformities and spinal curvature reduce lung space, making breathing difficult.